CAN THO CITY DEPARTMENT OF SCIENCE AND TECHNOLOGY
Innovative startup ecosystem: Adding external resources
The authors at Ho Chi Minh City International University have researched and successfully fabricated small-diameter artificial blood vessels from polymers with good mechanical properties, supporting endothelial cell growth and anti-clotting in blood vessels during transplantation for treatment of Cardiovascular disease.

Photo illustration

In cardiovascular medicine, surgery and transplantation are often the optimal treatment options. Currently, transplanted blood vessels can be obtained from the vascular portion of the patient's body, or from a suitable donor. However, this treatment often does not meet the needs of patients, due to many reasons, such as limited autologous vascular resources, high risk of thrombosis, infection from grafted vessels, etc. Therefore, an alternative is an artificial blood vessel, which maintains blood circulation and ensures normal physiological activity. The artificial blood vessels must have good mechanical properties, be suitable for blood pressure, allow endothelial cells to proliferate and most importantly prevent the formation of blood clots during transplantation.

Up to now, in Vietnam, large diameter artificial blood vessels (>6mm) have achieved certain success in the transplant and treatment related to blood vessels. Meanwhile, artificial blood vessels with a small diameter (≤6mm) still have limitations in strength and stiffness, leading to arterial blockage during the time the patient wears the implant.

Polyurethane (PU) and polycaprolactone (PCL) are considered as potential polymers for artificial vascular applications due to their good mechanical properties and high biocompatibility. PU has elasticity, good blood compatibility, can provide a mechanical environment similar to natural vascular tissues, especially to support endothelial cell proliferation. PCL is a hydrophobic polymer with mechanical properties ideally suited for the proliferation of endothelial cells, an important factor in preventing thrombus formation (clotting). In the country, there have been some studies on the use of PU/PCL to fabricate artificial blood vessels, but it is not anti-thrombotic, so it fails when transplanting. In addition, due to the inert and hydrophobic nature of the polymer, blood vessels made of PU/PCL fibers support endothelial cells to adhere and grow with low efficiency. There are also no studies on antithrombotic and surface denaturation that support endothelial cell proliferation of blood vessels made from PU/PCL.

Face with that fact, the authors at Ho Chi Minh City International University have carried out the project "Fabrication and improvement of surface antifreeze properties of poly-urethane/poly-caprolacton (PU/PCL) electrospun nano-films for circuit applications small-diameter artificial blood", in order to fabricate small-diameter blood vessels, improve the vessel wall surface with good mechanical properties, high biocompatibility, support endothelial cell growth and anti-coagulation blood during transplantation.

Accordingly, the authors used the electrospinning method (using electric field forces to pull out very thin fibers from the polymer solution), successfully fabricated PU/PCL artificial blood vessels, with a length of 5cm, diameter 6mm glass with tensile strength > 5Mpa.

During the fabrication process, the team used poloxamer 407 (a surfactant), which promotes cell adhesion and proliferation, and inhibits platelet adhesion for vascular engineering applications. In addition, poloxamer significantly enhances the wetting ability of the surface due to the hydrophilicity of the PEG (Polyethylene glycol) polymer blocks.

Laboratory tests have shown that the small diameter PU/PCL artificial blood vessel produced by the team is anti-thrombotic, can withstand blood pressure after implantation, and limits platelet adhesion. At the same time, preventing transmembrane leakage and permeability, which can be applied in vascular engineering, treatment of cardiovascular disease.

The project has been accepted by Ho Chi Minh City Department of Science and Technology in the past year.

ctngoc

www.khoahocphattrien.vn
Most viewed news

Vietnam Blockchain Association and Binance signed cooperation agreement

Accordingly, the two sides will cooperate to popularize blockchain in three areas: training, research and technology application.

Automatic system for handling residuals in mechanical processing

The system is manufactured by a group of authors at Nhat Tinh Technical Service Limitted Company, which can replace imports and improve competitiveness for domestic casting enterprises.

Launching Vietnam Blockchain Alliance

The Vietnam Blockchain Alliance under the Vietnam Digital Media Association has set itself a mission to connect the community and advise regulatory agencies to manage policies and legal frameworks on Blockchain, digital assets and money.

Vingroup AI Engineer Training Program: Opportunity to own scientific publications

During the 10-month training course, students have the opportunity to participate in large projects and own scientific publications in the fields of Biomedical Informatics, Medical Image Processing and Natural Language Processing.

Occupational safety and hygiene training course in 2022 in Can Tho

In the morning of June 17, 2022, Can Tho Center for Standards, Metrology and Quality Engineering (CATECH) under Can Tho City Department of Science and Technology coordinated with the Management Board of Can Tho Export Processing and Industrial Parks to organize a training course on occupational safety and hygiene in 2022 for staffs in charge of labor protection and occupational safety and hygiene network at enterprises.

Can Tho will take place workshop "Science, technology and innovation to promote digital transformation in agriculture" in 2022

The city-level scientific workshop with the topic "Science, technology and innovation promotes digital transformation in the agricultural sector" will take place on June 24.

The role of science and technology in digital transformation in agriculture

With the success of the 4th industrial revolution, digital transformation is now an inevitable trend, a matter of survival for countries, organizations, businesses and consumers around the world. Huge changes in labor productivity, user experiences and new business models are being formed, showing the great role and impact in today's social life of digital transformation to every industries, such as industry, commerce, healthcare, traffic, tourism, business services and etc.

Press release of the scientific workshop "Science, technology and innovation to promote digital transformation in agriculture"

Under the impact of the fourth industrial revolution, on the basis of achievements in science, technology and innovation, the digital transformation process has had a strong impact on most areas of the world economic and social life in each country in the world.

Propagating and disseminating knowledge of intellectual property and brand development

In the morning of June 15, 2022, Can Tho City Department of Science and Technology established a scientists team to evaluate the content and funding for the implementation of the project "Propaganda and dissemination of knowledge of intellectual property and brand development.” under the Program to develop intellectual property of Can Tho city until 2030. The appraisal team is led by Mr. Ngo Anh Tin – Director of the Department of Science and Technology of Can Tho city. The study is carried out by Mrs. Nguyen Thuy Hang. Can Tho Science and Technology Information Center is a presiding agency. The project implementation period is 24 months.

Related news
CAN THO CITY DEPARTMENT OF SCIENCE AND TECHNOLOGY

Copyright @ 2021 belongs to the Can Tho City Department of Science and Technology
Address: No. 02, Ly Thuong Kiet, Tan An Ward, Ninh Kieu District, Can Tho City
Phone: 0292.3820674, Fax: 0292.3821471; Email: sokhcn@cantho.gov.vn
Head of the Editorial Board: Ms. Tran Hoai Phuong - Deputy Director of the
Can Tho City Department of Science and Technology

Copyright © 2021 All rights reserved | This template is made by CASTI'1987